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West Indian Medical Journal

Print version ISSN 0043-3144


YU, X; ZUO, Q; CHAO, W  and  JIANG, R. The changes of muscle FGF-6 expression at different time points after exercise-induced muscle damage. West Indian med. j. [online]. 2013, vol.62, n.9, pp. 793-798. ISSN 0043-3144.

OBJECTIVE: To investigate the changes of fibroblast growth factor (FGF)-6 expression in the regeneration and repair process after exercise-induced muscle damage (EIMD) and the relationship with skeletal muscle regeneration and repair. METHODS: The expression of FGF-6 at different time points was examined by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry staining after a downhill treadmill exercise. Skeletal muscle injury and regeneration at different times after EIMD was assessed by haematoxylin and eosin (H & E) staining. RESULTS: The FGF-6 protein expression was initially elevated, followed by a gradual reduction, while the changes of FGF-6 mRNA were almost all raised after the treadmill exercise. CONCLUSION: The results point out that FGF-6 is closely related to skeletal muscle regeneration and repair, probably implying a dual function in muscle regeneration.

Keywords : Downhill treadmill; exercise; exercise-induced muscle damage; FGF-6; gastrocnemius; regeneration.

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